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A subset of equine oral squamous cell carcinomas is associated with Equus caballus papillomavirus 2 infection.
- Source :
-
Journal of comparative pathology [J Comp Pathol] 2023 Aug; Vol. 205, pp. 1-6. Date of Electronic Publication: 2023 Jul 19. - Publication Year :
- 2023
-
Abstract
- The aetiology of oral squamous cell carcinoma (SCC) in horses is unknown, but papillomavirus infection as well as chronic periodontal disease are suspected to play a pathogenic role. In humans, some oropharyngeal cancers develop in association with human papillomaviruses. Equus caballus papillomavirus 2 (EcPV2) is suspected to play a causal role in the development of equine genital SCC. Given that association, we hypothesized that EcPV2 is associated with the development of oral SCC in horses. We performed standard polymerase chain reaction (PCR) and in-situ hybridization (ISH) for EcPV2 on 31 formalin-fixed paraffin-embedded equine oral SCCs (lingual, gingival, palate) and 10 equine non-SCC oral samples. PCR for EcPV2 was positive in 10/31 (32%) oral SCCs while all non-SCC oral samples were negative. Intense hybridization signals for EcPV2 nucleic acid were detected by ISH within neoplastic epithelial cells in 8/31 (26%) oral SCCs but not in the adjacent normal oral mucosa. No hybridization signals were detected within control samples. This study provides additional support for a pathogenic association of EcPV2 in oral SCC in horses.<br /> (Copyright © 2023. Published by Elsevier Ltd.)
- Subjects :
- Horses
Humans
Animals
Squamous Cell Carcinoma of Head and Neck veterinary
DNA, Viral analysis
Papillomaviridae genetics
Carcinoma, Squamous Cell veterinary
Carcinoma, Squamous Cell pathology
Mouth Neoplasms veterinary
Papillomavirus Infections complications
Papillomavirus Infections veterinary
Horse Diseases pathology
Head and Neck Neoplasms veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 1532-3129
- Volume :
- 205
- Database :
- MEDLINE
- Journal :
- Journal of comparative pathology
- Publication Type :
- Academic Journal
- Accession number :
- 37478800
- Full Text :
- https://doi.org/10.1016/j.jcpa.2023.06.003