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Towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases?

Authors :
Blagosklonny MV
Source :
Aging [Aging (Albany NY)] 2023 Jul 20; Vol. 15 (14), pp. 6632-6640. Date of Electronic Publication: 2023 Jul 20.
Publication Year :
2023

Abstract

Both individuals taking rapamycin, an anti-aging drug, and those not taking it will ultimately succumb to age-related diseases. However, the former, if administered disease-oriented dosages for a long time, may experience a delayed onset of such diseases and live longer. The goal is to delay a particular disease that is expected to be life-limiting in a particular person. Age-related diseases, quasi-programmed during development, progress at varying rates in different individuals. Rapamycin is a prophylactic anti-aging drug that decelerates early development of age-related diseases. I further discuss hyperfunction theory of quasi-programmed diseases, which challenges the need for the traditional concept of aging itself.

Details

Language :
English
ISSN :
1945-4589
Volume :
15
Issue :
14
Database :
MEDLINE
Journal :
Aging
Publication Type :
Academic Journal
Accession number :
37477535
Full Text :
https://doi.org/10.18632/aging.204920