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Rosuvastatin-induced rhabdomyolysis: case report and call for proactive multifactorial risk assessment and preventive management of statin therapy in high-risk patients.
- Source :
-
European journal of hospital pharmacy : science and practice [Eur J Hosp Pharm] 2024 Apr 23; Vol. 31 (3), pp. 281-284. Date of Electronic Publication: 2024 Apr 23. - Publication Year :
- 2024
-
Abstract
- Cholesterol-lowering statins are frequently prescribed for primary and secondary prevention of ischaemic vascular events. Whereas most patients tolerate statins without problems, statin-associated myopathy is well documented, as are several risk factors. We present a case report of an 80-90-year-old man with coronary artery disease who rapidly developed severe rhabdomyolysis during treatment with rosuvastatin while in intensive care. He had several concomitant risk factors for statin-induced myopathy including high dosage, old age, renal and hepatic impairment, and a pharmacogenetic SLCO1B1*1 a/*5 variant. Single known risk factors have a low predictive value for statin-induced myopathy and may therefore be underestimated in clinical practice. However, adverse drug reactions frequently involve the joint action of a multitude of environmental and genetic component causes, and statin-induced myopathy should be regarded as a multicausal event. We therefore advocate a proactive multifactorial risk assessment to guide and individualise statin therapy in high-risk patients.<br />Competing Interests: Competing interests: None declared.<br /> (© European Association of Hospital Pharmacists 2024. Re-use permitted under CC BY-NC. No commercial re-use. Published by BMJ.)
- Subjects :
- Humans
Male
Risk Assessment
Aged, 80 and over
Risk Factors
Liver-Specific Organic Anion Transporter 1 genetics
Coronary Artery Disease
Rhabdomyolysis chemically induced
Rhabdomyolysis prevention & control
Hydroxymethylglutaryl-CoA Reductase Inhibitors adverse effects
Rosuvastatin Calcium adverse effects
Rosuvastatin Calcium therapeutic use
Rosuvastatin Calcium administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 2047-9956
- Volume :
- 31
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- European journal of hospital pharmacy : science and practice
- Publication Type :
- Academic Journal
- Accession number :
- 37451842
- Full Text :
- https://doi.org/10.1136/ejhpharm-2023-003765