Defining global strategies to improve outcomes in sickle cell disease: a Lancet Haematology Commission.

Competing Interests: Declaration of interests MRA has received grants or contracts with Novartis, Pfizer, Global Blood Therapeutics, and Forma Therapeutics; and participated in Data Safety Monitoring Boards or Advisory Boards for Vertex, GBT, Forma, Novartis, and Aggios. BA has participated in Data Safety Monitoring Boards or Advisory Boards for Agios, Aruvant, bluebird bio, CRISPR, Accordant (CVS), Emmaus, Forma Therapeutics, Fulcrum, Global Blood Therapeutics, Hemanext, Novartis, NovoNordisk, and Vertex. RF has received grants from the European Horizon 2020 and Horizon Europe schemes and a contract with Global Blood Therapeutics; received consulting fees from Novartis and Global Blood Therapeutics; received honoraria for a Physicians’ Education Resource and from Global Blood Therapeutics; participated in Data Safety Monitoring Boards or Advisory Boards for Vertex, Addmedica and Novonordisk; and a leadership or fiduciary role as a member of the Steering Committee and Coordinator of the Red Cell Disorder Working Group of the Italian Association of Pediatric Hematology Oncology. NC has received a research grant for Novartis Precision Medicine. MdM has received honoraria for presentations by Addmedica and Novartis and support from Addmedica for attending a conference; and participated in a Data Safety Monitoring Board or Advisory Board for Addmedica, Vertex, and Novartis. JE has received grants from the European Horizon 2020 scheme and participated in the Data Safety Monitoring Board or Advisory Board of the Fondation Pierre Fabre. EE has received consulting fees from bluebird bio. ALG has an honorary advisory role on the Australian Sickle Cell Advisory Board. IMI has received a grant from the American Society of Hematology; consulting fees from Agios Pharmaceuticals; and honoraria from the American Society of Hematology. LCJ received royalties for a book chapter. AAK has received support from the Health resources and Services Administration. MLP has received consulting fees from the American College of Medical Genetics and Genomics; and participated in a Data Safety Monitoring Board or Advisory Board for the American College of Medical Genetics and Genomics and the American Academy of Pediatrics. ON has received travel support from the American Society of Hematology to attend a conference. DCR has received consulting fees from Vertex, Forma, Agios, and Vifor; received honoraria from Vertex; and participated in a Data Safety Monitoring Board or Advisory Board for TauRx and Mitsubishi. AS has received a scholar award from the American Society of Hematology, an advancing cures research award from the Doris Duke Charitable Foundation, and a Working group award from the Center for ELSI Resources and Analysis; consulting fees from Spotlight Therapeutics, Medexus, Vertex, Editas Medicine, and Sangamo Therapeutics; has received honoraria from Vindico Medical Education; and has a leadership or fiduciary role in the American Society for Transplantation and Cellular Therapy Content Committee, the Scientific Executive Committee, Sickle Cell Transplant Advocacy & Research Alliance, and the Pediatric Transplantation and Cellular Therapy Consortium Supportive Care Committee; and has financial interests with CRISPR Therapeutics, Vertex Pharmaceuticals, Novartis Pharmaceuticals, Magenta Therapeutics, and Beam Therapeutics. AAT has received consulting fees from GlaxoSmithKline and Global Blood Therapeutics; and honoraria from Novartis. REW has received consulting fees from Nova Laboratories; participated in a Data Safety Monitoring Board for Novartis and Editas; and received donations and support for clinical trials from Bristol Myers Squib, Addmedica, and Hemex Health. DJW has received a grant or contract from the US National Institutes for Health; received payment for expert testimony from Fredslough Law Firm; participated in a Data Safety Monitoring Board or Advisory board for Northwestern University; and is the founder and chairman of eNursing.