A urokinase-associated outbreak of Ralstonia mannitolilytica bloodstream infections in haemodialysis patients in north-eastern Italy, January to April 2023.

Authors :: Fabricci M
Trinca A
Talotti L
Busetti M
Fotakis EA
Merakou C
Koncan R
Ghiotti A
Negri C
Di Maso V
Bosco M
Antonelli A
Coppi M
Rossolini GM
Giuliani C
Scarpis E
Gregoretti B
Licastro D
Luzzati R
Costantino V
Source :: Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin [Euro Surveill] 2023 Jul; Vol. 28 (28).
Publication Year :: 2023
Abstract: An outbreak of Ralstonia mannitolilytica bloodstream infections occurred in four hospitals in north-eastern Italy, involving 20 haemodialysis patients with tunnelled central vascular catheter access. We identified as the outbreak source a batch of urokinase vials imported from India contaminated with R. mannitolilytica. Whole genome sequences of the clinical and urokinase strains were highly related, and only urokinase-treated patients were reported with R. mannitolilytica infections (attack rate = 34%; 95% confidence interval: 22.1-47.4). Discontinuation of the contaminated urokinase terminated the outbreak.

Subjects :: Humans
Urokinase-Type Plasminogen Activator genetics
Urokinase-Type Plasminogen Activator therapeutic use
Renal Dialysis adverse effects
Disease Outbreaks
Gram-Negative Bacterial Infections diagnosis
Gram-Negative Bacterial Infections drug therapy
Gram-Negative Bacterial Infections epidemiology
Sepsis epidemiology

Language :: English
ISSN :: 1560-7917
Volume :: 28
Issue :: 28
Database :: MEDLINE
Journal :: Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
Publication Type :: Academic Journal
Accession number :: 37440346
Full Text :: https://doi.org/10.2807/1560-7917.ES.2023.28.28.2300328

Full Text Access

Tools