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Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1Alpha (PGC-1α): A Transcriptional Regulator at the Interface of Aging and Age-Related Macular Degeneration?
- Source :
-
Advances in experimental medicine and biology [Adv Exp Med Biol] 2023; Vol. 1415, pp. 49-53. - Publication Year :
- 2023
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Abstract
- Human age-related macular degeneration (AMD) is a prevalent age-related disease which causes retinal dysfunction and disability. Genetic and cell culture studies from AMD patients have implicated impaired activity of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1α). PGC-1α is a transcriptional co-regulator that acts to control a plethora of metabolic processes relevant to AMD pathophysiology including gluconeogenesis, oxidative phosphorylation, and response to oxidative injury. Perturbation of PGC-1α activity in mice causes AMD-like RPE and retinal pathology. There is potential for therapeutic modulation of the PGC-1α pathway in AMD treatment.<br /> (© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.)
Details
- Language :
- English
- ISSN :
- 0065-2598
- Volume :
- 1415
- Database :
- MEDLINE
- Journal :
- Advances in experimental medicine and biology
- Publication Type :
- Academic Journal
- Accession number :
- 37440013
- Full Text :
- https://doi.org/10.1007/978-3-031-27681-1_8