Back to Search
Start Over
Carbonic anhydrase inhibitory activity of phthalimide-capped benzene sulphonamide derivatives.
- Source :
-
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2235089. - Publication Year :
- 2023
-
Abstract
- A series of phthalimide-capped benzene sulphonamides ( 1 - 22 ) reported by our group for dengue protease inhibitory activity have been evaluated for their carbonic anhydrase (hCA, EC 4.2.1.1) inhibitory activity against hCA I, hCA II. Compounds 1 , 3 , 10 , and 15 showed hCA I inhibition, whereas 1 , 4 , and 10 showed hCA II inhibition at nanomolar concentrations. Among these compounds, 1 displayed potent inhibitory activity against the hCA I (Ki = 28.5 nM) and hCA II (Ki = 2.2 nM), being 10 and 6 times more potent than acetazolamide, a standard inhibitor (Ki = 250 nM and 12 nM), respectively. Furthermore, this compound displayed 14-fold selectivity towards the hCA II isoform compared to hCA I. Molecular docking and MD simulations were performed to understand the atomic level interactions responsible for the selectivity of compound 1 towards hCA II.
Details
- Language :
- English
- ISSN :
- 1475-6374
- Volume :
- 38
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of enzyme inhibition and medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 37439360
- Full Text :
- https://doi.org/10.1080/14756366.2023.2235089