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Short-course antibiotic therapy for pneumonia in the neonatal intensive care unit.
- Source :
-
Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2023 Sep; Vol. 43 (9), pp. 1145-1151. Date of Electronic Publication: 2023 Jul 12. - Publication Year :
- 2023
-
Abstract
- Objective: To determine the adherence and safety outcomes of a 5-day antibiotic course with a "time-out" for treatment of "blood culture-negative" pneumonia in the NICU.<br />Study Design: Prospective surveillance of all infants diagnosed with pneumonia at 7 NICUs from 8/2020-12/2021. Safety outcomes were defined a priori by re-initiation of antibiotic therapy within 14 days after discontinuation and overall and sepsis-related mortality.<br />Results: 128 infants were diagnosed with 136 episodes of pneumonia; 88% (n = 119) were treated with 5 days of definitive antibiotic therapy. Antibiotics were restarted within 14 days in 22 (16%) of the 136 pneumonia episodes. However, only 3 (3%) of the 119 episodes of pneumonia treated for 5 days had antibiotics restarted for pneumonia. Mortality was 5% (7/128); 5 of the 7 deaths were assessed as sepsis-related.<br />Conclusion: Adherence to the 5-day definitive antibiotic treatment for "culture-negative" pneumonia was high and the intervention seemed safe.<br /> (© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Details
- Language :
- English
- ISSN :
- 1476-5543
- Volume :
- 43
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of perinatology : official journal of the California Perinatal Association
- Publication Type :
- Academic Journal
- Accession number :
- 37438484
- Full Text :
- https://doi.org/10.1038/s41372-023-01720-6