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Phorbol ester inhibition of vasopressin-induced calcium efflux from cultured rat aortic myocytes.
- Source :
-
FEBS letters [FEBS Lett] 1986 Sep 15; Vol. 205 (2), pp. 251-4. - Publication Year :
- 1986
-
Abstract
- The effect of the protein kinase C activator TPA was investigated on AVP-induced 45Ca release from rat aortic myocytes. In the nanomolar range TPA, but not 4 beta-phorbol, reduced the brief 45Ca efflux produced by AVP in the presence or in the absence of extracellular calcium. The maximal effect of TPA was to abolish the response to a half maximally active concentration of AVP, and to reduce by 50% the maximal response to the hormone. These results suggest that protein kinase C activation can exert a negative control on the early AVP-induced calcium mobilization in vascular smooth muscle.
Details
- Language :
- English
- ISSN :
- 0014-5793
- Volume :
- 205
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- FEBS letters
- Publication Type :
- Academic Journal
- Accession number :
- 3743776
- Full Text :
- https://doi.org/10.1016/0014-5793(86)80907-3