Back to Search Start Over

Human adenovirus associated with severe cold agglutinin syndrome: a rare complication in Pediatrics.

Authors :
Sion JL
Flores ALH
Cardoso RA
Garanito MP
Source :
Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo [Rev Paul Pediatr] 2023 Jul 10; Vol. 42, pp. e2022174. Date of Electronic Publication: 2023 Jul 10 (Print Publication: 2023).
Publication Year :
2023

Abstract

Objective: The objectives of this study were to describe the first pediatric case of cold agglutinin syndrome (CAS) triggered by human adenovirus and review the literature.<br />Case Description: This case report involves a previously healthy, 2½-year-old female child with human adenovirus isolated in a nasal swab. At 72 h after admission, the patient progressed to a severe episode of anemia (hemoglobin level: 2.6 g/dL). The laboratory findings were consistent with CAS. The patient received blood transfusion, vitamin supplementation, adequate hydration, and thermal protection. At her last follow-up, 1 year after her initial presentation, she remains clinically well without signs of hemolysis.<br />Comments: While severe CAS is extremely uncommon in the pediatric emergency department, human adenovirus infection is a common illness in pediatrics. Recently, the adenovirus has been associated with new complications (acute hepatitis and fulminant liver failure). Pediatric physicians and hematologists should be aware of unusual evolution, signs, and symptoms of this infection that warrant more urgent medical attention. In this case, the hematologic complication suspicion was the key to early diagnosis and adequate management.

Details

Language :
English
ISSN :
1984-0462
Volume :
42
Database :
MEDLINE
Journal :
Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo
Publication Type :
Academic Journal
Accession number :
37436249
Full Text :
https://doi.org/10.1590/1984-0462/2024/42/2022174