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An intercommunicated nanosystem for dual delivery.

Authors :
Mayol B
Rodríguez A
Villalonga A
Anillo C
Vilela D
Sánchez A
Martínez-Ruiz P
Villalonga R
Source :
Journal of materials chemistry. B [J Mater Chem B] 2023 Aug 02; Vol. 11 (30), pp. 7190-7196. Date of Electronic Publication: 2023 Aug 02.
Publication Year :
2023

Abstract

Here, we describe the design of a novel particle-to-particle intercommunicated nanosystem for dual delivery, triggered by physical and chemical inputs. The nanosystem was composed of an Au-mesoporous silica Janus nanoparticle loaded with paracetamol, mechanized with light-sensitive supramolecular gates at the mesoporous face and functionalized on the metal surface with the enzyme acetylcholinesterase. The second component was a mesoporous silica nanoparticle loaded with rhodamine B and gated with thiol-sensitive ensembles. Upon irradiation of this nanosystem with a near-UV light laser, an analgesic drug was released from the Janus nanomachine due to disassembling of the photosensitive gating mechanism. Further addition of N -acetylthiocholine leads to the enzymatic production of thiocholine at the Janus nanomachine, thus acting as a "chemical messenger" causing the disruption of the gating mechanism at the second mesoporous silica nanoparticle with the subsequent dye release.

Details

Language :
English
ISSN :
2050-7518
Volume :
11
Issue :
30
Database :
MEDLINE
Journal :
Journal of materials chemistry. B
Publication Type :
Academic Journal
Accession number :
37417457
Full Text :
https://doi.org/10.1039/d3tb00512g