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Access to distal meta -C-H functionalization of arylmethanesulfonic acid derivatives.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2023 Jul 20; Vol. 59 (59), pp. 9106-9109. Date of Electronic Publication: 2023 Jul 20. - Publication Year :
- 2023
-
Abstract
- Herein, we report the meta -C-H olefination of arylmethanesulfonates aided by a potentially versatile aliphatic nitrile-directing group under microwave irradiation conditions with fair to very good yields and good to outstanding regioselectivities. Significantly, the protocol showed broad substrate scope including olefin-derived drugs and cyclic olefins. Remarkably, a dual meta -C-H bond was amenable to generating the bis-olefination products.
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 59
- Issue :
- 59
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 37403674
- Full Text :
- https://doi.org/10.1039/d3cc02260a