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Anticancer properties of sulforaphane: current insights at the molecular level.

Authors :: Asif Ali M
Khan N
Kaleem N
Ahmad W
Alharethi SH
Alharbi B
Alhassan HH
Al-Enazi MM
Razis AFA
Modu B
Calina D
Sharifi-Rad J
Source :: Frontiers in oncology [Front Oncol] 2023 Jun 16; Vol. 13, pp. 1168321. Date of Electronic Publication: 2023 Jun 16 (Print Publication: 2023).
Publication Year :: 2023
Abstract: Sulforaphane (SFN) is an isothiocyanate with multiple biomedical applications. Sulforaphane can be extracted from the plants of the genus Brassica . However, broccoli sprouts are the chief source of sulforaphane and are 20 to 50 times richer than mature broccoli as they contain 1,153 mg/100 g. SFN is a secondary metabolite that is produced as a result of the hydrolysis of glucoraphanin (a glucosinolate) by the enzyme myrosinase. This review paper aims to summarize and understand the mechanisms behind the anticancer potential of sulforaphane. The data was collected by searching PubMed/MedLine, Scopus, Web of Science, and Google Scholar. This paper concludes that sulforaphane provides cancer protection through the alteration of various epigenetic and non-epigenetic pathways. It is a potent anticancer phytochemical that is safe to consume with minimal side effects. However, there is still a need for further research regarding SFN and the development of a standard dose.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2023 Asif Ali, Khan, Kaleem, Ahmad, Alharethi, Alharbi, Alhassan, Al-Enazi, Razis, Modu, Calina and Sharifi-Rad.)