O-GlcNAcylation: A Crucial Regulator in Cancer-Associated Biological Events.

Authors :: Ran Z
Zhang L
Dong M
Zhang Y
Chen L
Song Q
Source :: Cell biochemistry and biophysics [Cell Biochem Biophys] 2023 Sep; Vol. 81 (3), pp. 383-394. Date of Electronic Publication: 2023 Jul 01.
Publication Year :: 2023
Abstract: O-GlcNAcylation, a recently discovered post-translational modification of proteins, plays a crucial role in regulating protein structure and function, and is closely associated with multiple diseases. Research has shown that O-GlcNAcylation is abnormally upregulated in most cancers, promoting disease progression. To elucidate the roles of O-GlcNAcylation in cancer, this review summarizes various cancer-associated biological events regulated by O-GlcNAcylation and the corresponding signaling pathways. This work may provide insights for future studies on the function or underlying mechanisms of O-GlcNAcylation in cancer.<br /> (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)