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Rationale and clinical application of antimicrobial stewardship principles in the intensive care unit: a multidisciplinary statement.
- Source :
-
Journal of anesthesia, analgesia and critical care [J Anesth Analg Crit Care] 2023 May 01; Vol. 3 (1), pp. 11. Date of Electronic Publication: 2023 May 01. - Publication Year :
- 2023
-
Abstract
- Background: Antimicrobial resistance represents a major critical issue for the management of the critically ill patients hospitalized in the intensive care unit (ICU), since infections by multidrug-resistant bacteria are characterized by high morbidity and mortality, high rates of treatment failure, and increased healthcare costs worldwide. It is also well known that antimicrobial resistance can emerge as a result of inadequate antimicrobial therapy, in terms of drug selection and/or treatment duration. The application of antimicrobial stewardship principles in ICUs improves the quality of antimicrobial therapy management. However, it needs specific considerations related to the critical setting.<br />Methods: The aim of this consensus document gathering a multidisciplinary panel of experts was to discuss principles of antimicrobial stewardship in ICU and to produce statements that facilitate their clinical application and optimize their effectiveness. The methodology used was a modified nominal group discussion.<br />Conclusion: The final set of statements underlined the importance of the specific interpretation of antimicrobial stewardship's principles in critically ill patient management, quasi-targeted therapy, the use of rapid diagnostic methods, the personalization of antimicrobial therapies' duration, obtaining microbiological surveillance data, the use of PK/PD targets, and the use of specific indicators in antimicrobial stewardship programs.<br /> (© 2023. The Author(s).)
Details
- Language :
- English
- ISSN :
- 2731-3786
- Volume :
- 3
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of anesthesia, analgesia and critical care
- Publication Type :
- Academic Journal
- Accession number :
- 37386615
- Full Text :
- https://doi.org/10.1186/s44158-023-00095-6