Severe homozygous HbE disease: the first case report from Nepal.

Authors :: Bhattarai U
Adhikari D
Gautam A
Anand A
Shah B
Sharma SK
Source :: Oxford medical case reports [Oxf Med Case Reports] 2023 Jun 26; Vol. 2023 (6), pp. omad062. Date of Electronic Publication: 2023 Jun 26 (Print Publication: 2023).
Publication Year :: 2023
Abstract: Hemoglobin E (HbE) is the most prevalent hemoglobinopathy in the eastern Indian subcontinent. We presented the case of a 53-year-old male from Nepal with a history of multiple blood transfusions who presented with abdominal fullness for 15 years and easy fatigability for 2 months. He had pallor and massive splenomegaly. Laboratory parameters showed pancytopenia with microcytic anemia, indirect hyperbilirubinemia, target cells in the peripheral smear and iron overload. A computed tomography scan of the abdomen showed multiple splenic infarcts. Hemoglobin electrophoresis was suggestive of HbE homozygous disease. Based on these findings, we made a diagnosis of HbE homozygous disease. We provided symptomatic treatment and folic acid supplementation and counseled him for splenectomy and genetic screening. Our case highlighted the uncommon presentation of Hb E disease.<br />Competing Interests: None declared.<br /> (© The Author(s) 2023. Published by Oxford University Press.)