Back to Search
Start Over
A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study.
- Source :
-
Biomimetics (Basel, Switzerland) [Biomimetics (Basel)] 2023 May 31; Vol. 8 (2). Date of Electronic Publication: 2023 May 31. - Publication Year :
- 2023
-
Abstract
- The production of anthropomorphic phantoms generated from tissue-equivalent materials is challenging but offers an excellent copy of the typical environment encountered in typical patients. High-quality dosimetry measurements and the correlation of the measured dose with the biological effects elicited by it are a prerequisite in preparation of clinical trials with novel radiotherapy approaches. We designed and produced a partial upper arm phantom from tissue-equivalent materials for use in experimental high-dose-rate radiotherapy. The phantom was compared to original patient data using density values and Hounsfield units obtained from CT scans. Dose simulations were conducted for broad-beam irradiation and microbeam radiotherapy (MRT) and compared to values measured in a synchrotron radiation experiment. Finally, we validated the phantom in a pilot experiment with human primary melanoma cells.
Details
- Language :
- English
- ISSN :
- 2313-7673
- Volume :
- 8
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biomimetics (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 37366825
- Full Text :
- https://doi.org/10.3390/biomimetics8020230