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Plasma free and conjugated catecholamines in clinical disorders.
- Source :
-
Life sciences [Life Sci] 1986 Aug 11; Vol. 39 (6), pp. 557-64. - Publication Year :
- 1986
-
Abstract
- Plasma free and sulfoconjugated norepinephrine (NE), epinephrine (E) and dopamine (DA) concentrations measured in patients with thrombocytopenia or thrombocytosis, in newborns and pregnant women were not statistically different from values determined in 41 healthy volunteers. The percentage free to total NE, E and DA was 30 +/- 10%, 35 +/- 11% and 1.5 +/- 1.1% (mean +/- SE) in the controls, resp; not different from the previously described patients or from patients with liver failure who showed significantly higher free and conjugated NE and E levels when compared with controls (p less than 0.01, resp.). Conjugated catecholamine (CA) levels from the femoral artery and from multiple sites in the venous system sampled in patients undergoing intracardiac measurements were identical. The data suggest that sulfation of CA may not be simply ascribed to platelets, to the liver, to vascular beds, or to organs along the vena cava including the adrenal glands. The parallel increase of free and conjugated NE with age in healthy controls, as well as the unchanged degree of conjugation in patients with increased spillover of NE and E caused by a pheochromocytoma or by a heart attack, suggest that there is a balance between free and sulfated CA. A normal ratio of free to conjugated NE and E observed in patients receiving high dosage DA infusion further indicates that there is an adequate sulfate supply and no apparent substrate inhibition of the conjugation process. Because the percentage free of total NE, E and DA were significantly lower in patients in the hypothyroid state when compared with controls (p less than 0.01, resp.), hypothyroidism may affect the balance of free to conjugated CA in a yet unknown way.
- Subjects :
- Adolescent
Adrenal Gland Neoplasms blood
Adult
Aged
Cardiac Catheterization
Dopamine metabolism
Epinephrine metabolism
Female
Humans
Hyperthyroidism blood
Hypothyroidism blood
Infant, Newborn
Liver Diseases blood
Male
Middle Aged
Myocardial Infarction blood
Norepinephrine metabolism
Pheochromocytoma blood
Pregnancy
Sulfates metabolism
Thrombocytopenia blood
Thrombocytosis blood
Dopamine blood
Epinephrine blood
Norepinephrine blood
Subjects
Details
- Language :
- English
- ISSN :
- 0024-3205
- Volume :
- 39
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Life sciences
- Publication Type :
- Academic Journal
- Accession number :
- 3736337
- Full Text :
- https://doi.org/10.1016/0024-3205(86)90513-8