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Human disease models in drug development.
- Source :
-
Nature reviews bioengineering [Nat Rev Bioeng] 2023 May 11, pp. 1-15. Date of Electronic Publication: 2023 May 11. - Publication Year :
- 2023
- Publisher :
- Ahead of Print
-
Abstract
- Biomedical research is undergoing a paradigm shift towards approaches centred on human disease models owing to the notoriously high failure rates of the current drug development process. Major drivers for this transition are the limitations of animal models, which, despite remaining the gold standard in basic and preclinical research, suffer from interspecies differences and poor prediction of human physiological and pathological conditions. To bridge this translational gap, bioengineered human disease models with high clinical mimicry are being developed. In this Review, we discuss preclinical and clinical studies that benefited from these models, focusing on organoids, bioengineered tissue models and organs-on-chips. Furthermore, we provide a high-level design framework to facilitate clinical translation and accelerate drug development using bioengineered human disease models.<br />Competing Interests: Competing interestsThe authors state no competing interests.<br /> (© Springer Nature Limited 2023, corrected publication 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
Details
- Language :
- English
- ISSN :
- 2731-6092
- Database :
- MEDLINE
- Journal :
- Nature reviews bioengineering
- Publication Type :
- Academic Journal
- Accession number :
- 37359774
- Full Text :
- https://doi.org/10.1038/s44222-023-00063-3