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Effect of mannitol-based reduced-volume hydration on kidney function in concomitant cisplatin-based chemoradiation for head-and-neck squamous cell carcinoma.
- Source :
-
Head & neck [Head Neck] 2023 Aug; Vol. 45 (8), pp. 2087-2097. Date of Electronic Publication: 2023 Jun 22. - Publication Year :
- 2023
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Abstract
- Objective: Nephrotoxicity is frequent in cisplatin-based chemoradiation of head and neck squamous cell carcinoma (HNSCC). Toxicity outcomes and achieved cisplatin-doses after change of departmental hydration policy are presented.<br />Methods: We performed a retrospective time-series analysis of HNSCC patients undergoing chemoradiation with conventional hydration (CH) between 01/2017 and 09/2018 versus shorter hydration with mannitol (SHM) between 09/2018 and 08/2019 to compare the rate of acute kidney injury (AKI) and cumulative cisplatin dose.<br />Results: Among 113 HNSCC patients, SHM (n = 35) in comparison to CH (n = 78) correlated with less AKI (54.3% vs. 74.4%; p = 0.034) and higher cisplatin doses (82.9% vs. 61.5% ≥200 mg/m <superscript>2</superscript> ; p = 0.025). AKI ≥grade 2 was lower with SHM (2.9% vs. CH: 22.8%; p = 0.01). AKI occurred more frequently in females (92.6% vs. males: 60.5%, p = 0.002). Females received lower cumulative cisplatin doses (51.9% vs. males: 73.3%; p = 0.037).<br />Conclusions: We observed less AKI and higher cumulative chemotherapy doses with SHM. Female patients were at higher risk of AKI.<br /> (© 2023 The Authors. Head & Neck published by Wiley Periodicals LLC.)
- Subjects :
- Male
Humans
Female
Cisplatin adverse effects
Squamous Cell Carcinoma of Head and Neck drug therapy
Mannitol therapeutic use
Retrospective Studies
Kidney
Antineoplastic Agents adverse effects
Head and Neck Neoplasms drug therapy
Acute Kidney Injury chemically induced
Acute Kidney Injury drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0347
- Volume :
- 45
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Head & neck
- Publication Type :
- Academic Journal
- Accession number :
- 37345576
- Full Text :
- https://doi.org/10.1002/hed.27438