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The evaluation of JAK inhibitors on effect and safety in alopecia areata: a systematic review and meta-analysis of 2018 patients.

Authors :
Mao MQ
Ding YX
Jing J
Tang ZW
Miao YJ
Yang XS
Chen YH
Chen SZ
Wu XJ
Lu ZF
Source :
Frontiers in immunology [Front Immunol] 2023 Jun 02; Vol. 14, pp. 1195858. Date of Electronic Publication: 2023 Jun 02 (Print Publication: 2023).
Publication Year :
2023

Abstract

Background: JAK inhibitors treat various autoimmune diseases, but an updated systematic review in treating alopecia areata is currently lacking.<br />Objective: Evaluate the specific efficacy and safety of JAK inhibitors in alopecia areata by systematic review and meta-analysis.<br />Methods: Eligible studies in PubMed, Embase, Web of Science, and Clinical Trials up to May 30, 2022, were searched. We enrolled in randomized controlled trials and observational studies of applying JAK inhibitors in alopecia areata.<br />Results: 6 randomized controlled trials with 1455 patients exhibited SALT <subscript>50</subscript> (odd ratio [OR], 5.08; 95% confidence interval [CI], 3.49-7.38), SALT <subscript>90</subscript> (OR, 7.40; 95% CI, 4.34-12.67) and change in SALT score (weighted mean difference [WSD], 5.55; 95% CI, 2.60-8.50) compared to the placebo. The proportion of 26 observational studies with 563 patients of SALT <subscript>5</subscript> was 0.71(95% CI, 0.65-0.78), SALT <subscript>50</subscript> was 0.54(95% CI 0.46-0.63), SALT <subscript>90</subscript> was 0.33(95% CI, 0.24-0.42), and SALT score (WSD, -2.18; 95% CI, -3.12 to -1.23) compared with baseline. Any adverse effects occurred in 921 of 1508 patients; a total of 30 patients discontinued the trial owing to adverse reactions.<br />Limitations: Few randomized controlled trials met the inclusion criteria and insufficiency of eligible data.<br />Conclusion: JAK inhibitors are effective in alopecia areata, although associated with an increased risk.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2023 Mao, Ding, Jing, Tang, Miao, Yang, Chen, Chen, Wu and Lu.)

Details

Language :
English
ISSN :
1664-3224
Volume :
14
Database :
MEDLINE
Journal :
Frontiers in immunology
Publication Type :
Academic Journal
Accession number :
37334349
Full Text :
https://doi.org/10.3389/fimmu.2023.1195858