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Transforming Cancer-Associated Fibroblast Barrier into Drug Depots to Boost Chemo-Immunotherapy in "Shooting Fish in a Barrel" Pattern.
- Source :
-
ACS nano [ACS Nano] 2023 Jul 25; Vol. 17 (14), pp. 13611-13626. Date of Electronic Publication: 2023 Jun 16. - Publication Year :
- 2023
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Abstract
- The cancer-associated fibroblast (CAF) barrier in pancreatic ductal adenocarcinoma (PDAC) greatly restricts clinical outcomes. Major obstacles to PDAC treatment include restricted immune cell infiltration and drug penetration and the immunosuppressive microenvironment. Here, we reported a "shooting fish in a barrel" strategy by preparing a lipid-polymer hybrid drug delivery system (PI/JGC/L-A) that could overcome the CAF barrier by turning it into a "barrel" with antitumor drug depot properties to alleviate the immunosuppressive microenvironment and increase immune cell infiltration. PI/JGC/L-A is composed of a pIL-12-loaded polymeric core (PI) and a JQ1 and gemcitabine elaidate coloaded liposomal shell (JGC/L-A) that has the ability to stimulate exosome secretion. By normalizing the CAF barrier to create a CAF "barrel" with JQ1, stimulating the secretion of gemcitabine-loaded exosomes from the CAF "barrel" to the deep tumor site, and leveraging the CAF "barrel" to secrete IL-12, PI/JGC/L-A realized effective drug delivery to the deep tumor site, activated antitumor immunity at the tumor site, and produced significant antitumor effects. In summary, our strategy of transforming the CAF barrier into antitumor drug depots represents a promising strategy against PDAC and might benefit the treatment of any tumors facing a drug delivery barrier.
- Subjects :
- Animals
Pharmaceutical Preparations
Immunotherapy
Tumor Microenvironment
Cell Line, Tumor
Pancreatic Neoplasms
Cancer-Associated Fibroblasts
Pancreatic Neoplasms drug therapy
Pancreatic Neoplasms pathology
Carcinoma, Pancreatic Ductal drug therapy
Carcinoma, Pancreatic Ductal pathology
Antineoplastic Agents pharmacology
Antineoplastic Agents therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1936-086X
- Volume :
- 17
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- ACS nano
- Publication Type :
- Academic Journal
- Accession number :
- 37326384
- Full Text :
- https://doi.org/10.1021/acsnano.3c02272