Back to Search Start Over

Cytomegalovirus in children undergoing haematopoietic stem cell transplantation: a diagnostic and therapeutic approach to antiviral resistance.

Authors :
Hume J
Sweeney EL
Lowry K
Fraser C
Clark JE
Whiley DM
Irwin AD
Source :
Frontiers in pediatrics [Front Pediatr] 2023 May 30; Vol. 11, pp. 1180392. Date of Electronic Publication: 2023 May 30 (Print Publication: 2023).
Publication Year :
2023

Abstract

Cytomegalovirus (CMV) is a ubiquitous virus which causes a mild illness in healthy individuals. In immunocompromised individuals, such as children receiving haematopoietic stem cell transplantation, CMV can reactivate, causing serious disease and increasing the risk of death. CMV can be effectively treated with antiviral drugs, but antiviral resistance is an increasingly common complication. Available therapies are associated with adverse effects such as bone marrow suppression and renal impairment, making the choice of appropriate treatment challenging. New agents are emerging and require evaluation in children to establish their role. This review will discuss established and emerging diagnostic tools and treatment options for CMV, including antiviral resistant CMV, in children undergoing haematopoietic stem cell transplant.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (© 2023 Hume, Sweeney, Lowry, Fraser, Clark, Whiley and Irwin.)

Details

Language :
English
ISSN :
2296-2360
Volume :
11
Database :
MEDLINE
Journal :
Frontiers in pediatrics
Publication Type :
Academic Journal
Accession number :
37325366
Full Text :
https://doi.org/10.3389/fped.2023.1180392