Switch-on luminescent sensing of unlabelled bacterial lectin by terbium(III) glycoconjugate systems.

Authors :: Wojtczak K
Zahorska E
Murphy IJ
Koppel F
Cooke G
Titz A
Byrne JP
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2023 Jul 04; Vol. 59 (54), pp. 8384-8387. Date of Electronic Publication: 2023 Jul 04.
Publication Year :: 2023
Abstract: Interactions of lectins with glycoconjugate-terbium(III) self-assembly complexes lead to sensing through enhanced lanthanide luminescence. This glycan-directed sensing paradigm detects an unlabelled lectin (LecA) associated with pathogen P. aeruginosa in solution, without any bactericidal activity. Further development of these probes could have potential as a diagnostic tool.

Subjects :: Lectins chemistry
Luminescence
Glycoconjugates chemistry
Glycosides chemistry
Ligands
Bacterial Proteins chemistry
Terbium chemistry
Bacteria chemistry

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