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High-throughput measurement of the content and properties of nano-sized bioparticles with single-particle profiler.
- Source :
-
Nature biotechnology [Nat Biotechnol] 2024 Apr; Vol. 42 (4), pp. 587-590. Date of Electronic Publication: 2023 Jun 12. - Publication Year :
- 2024
-
Abstract
- We introduce a method, single-particle profiler, that provides single-particle information on the content and biophysical properties of thousands of particles in the size range 5-200 nm. We use our single-particle profiler to measure the messenger RNA encapsulation efficiency of lipid nanoparticles, the viral binding efficiencies of different nanobodies, and the biophysical heterogeneity of liposomes, lipoproteins, exosomes and viruses.<br /> (© 2023. The Author(s).)
- Subjects :
- Particle Size
Liposomes chemistry
Nanoparticles chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1546-1696
- Volume :
- 42
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Nature biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 37308687
- Full Text :
- https://doi.org/10.1038/s41587-023-01825-5