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The first reported case of double trisomy 10 and 20 in a product of conception.
- Source :
-
Laboratory medicine [Lab Med] 2024 Mar 07; Vol. 55 (2), pp. 245-248. - Publication Year :
- 2024
-
Abstract
- Background: Double trisomies are rare findings among products of conception and are often lethal to the developing embryo or fetus.<br />Methods: Here we describe a double trisomy case with symptoms of threatened miscarriage at 9 weeks gestation. Ultrasound revealed an anembryonic pregnancy. Pregnancy was terminated by dilation and curettage at gestational age 11 weeks and 6 days. Histologic examination and chromosome microarray were performed on a formalin-fixed product of conception (POC) sample to identify the cause of the anembryonic pregnancy.<br />Results: Chromosome microarray analysis revealed a female chromosome complement with double trisomies 10 and 20, arr(10,20)x3, consistent with a karyotype of 48,XX,+10,+20.<br />Conclusion: To the best of our knowledge, this is the first reported case of double trisomy 10 and 20 in a POC. Due to nonspecific histopathological findings, chromosomal microarray is a powerful tool in identifying and differentiating chromosomal aneuploidies.<br /> (© The Author(s) 2023. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Details
- Language :
- English
- ISSN :
- 1943-7730
- Volume :
- 55
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Laboratory medicine
- Publication Type :
- Academic Journal
- Accession number :
- 37294932
- Full Text :
- https://doi.org/10.1093/labmed/lmad052