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Unfavorable early-stage Hodgkin lymphoma: assessment of patient characteristics in a real-world setting.

Authors :
Gautam S
Yeola S
Nahar A
Sarpong EM
Prescott J
Yang X
Sineshaw HM
Source :
Future oncology (London, England) [Future Oncol] 2023 Jun; Vol. 19 (18), pp. 1249-1259. Date of Electronic Publication: 2023 Jun 09.
Publication Year :
2023

Abstract

Aim: Unfavorable prognostic factors among classical Hodgkin lymphoma (cHL) patients in the real-world setting have yet to be fully characterized. Methods: In this retrospective study using the ConcertAI Oncology Dataset, patient characteristics, unfavorable prognostic factors and treatment patterns were evaluated among patients diagnosed with cHL. Results: Among 324 adult cHL patients diagnosed 2016-2021, 16.1% were classified as early favorable, 32.7% early unfavorable and 51.2% advanced disease. Early unfavorable patients were younger and had a larger nodal mass. The prognostic factor B symptoms was most frequently documented in early unfavorable patients (59.4%), followed by bulky disease (46.2%), >3 involved lymph node regions (31.1%), and erythrocyte sedimentation rate ≥50 (25.5%). Conclusion: In this analysis of real-world data, we found that nearly a third of newly diagnosed cHL patients had early unfavorable disease. Our analysis also showed differences in the proportion of patients for each unfavorable factor among patients with early-stage unfavorable cHL.

Details

Language :
English
ISSN :
1744-8301
Volume :
19
Issue :
18
Database :
MEDLINE
Journal :
Future oncology (London, England)
Publication Type :
Academic Journal
Accession number :
37293737
Full Text :
https://doi.org/10.2217/fon-2022-0963