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Autoantigen profiling reveals a shared post-COVID signature in fully recovered and long COVID patients.
- Source :
-
JCI insight [JCI Insight] 2023 Jun 08; Vol. 8 (11). Date of Electronic Publication: 2023 Jun 08. - Publication Year :
- 2023
-
Abstract
- Some individuals do not return to baseline health following SARS-CoV-2 infection, leading to a condition known as long COVID. The underlying pathophysiology of long COVID remains unknown. Given that autoantibodies have been found to play a role in severity of SARS-CoV-2 infection and certain other post-COVID sequelae, their potential role in long COVID is important to investigate. Here, we apply a well-established, unbiased, proteome-wide autoantibody detection technology (T7 phage-display assay with immunoprecipitation and next-generation sequencing, PhIP-Seq) to a robustly phenotyped cohort of 121 individuals with long COVID, 64 individuals with prior COVID-19 who reported full recovery, and 57 pre-COVID controls. While a distinct autoreactive signature was detected that separated individuals with prior SARS-CoV-2 infection from those never exposed to SARS-CoV-2, we did not detect patterns of autoreactivity that separated individuals with long COVID from individuals fully recovered from COVID-19. These data suggest that there are robust alterations in autoreactive antibody profiles due to infection; however, no association of autoreactive antibodies and long COVID was apparent by this assay.
- Subjects :
- Humans
SARS-CoV-2
Autoantibodies
Autoantigens
Post-Acute COVID-19 Syndrome
COVID-19
Subjects
Details
- Language :
- English
- ISSN :
- 2379-3708
- Volume :
- 8
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- JCI insight
- Publication Type :
- Academic Journal
- Accession number :
- 37288661
- Full Text :
- https://doi.org/10.1172/jci.insight.169515