Back to Search
Start Over
Modification of the diabetes prevention program for the treatment of nonalcoholic fatty liver disease: A pilot study.
- Source :
-
Obesity science & practice [Obes Sci Pract] 2022 Oct 20; Vol. 9 (3), pp. 218-225. Date of Electronic Publication: 2022 Oct 20 (Print Publication: 2023). - Publication Year :
- 2022
-
Abstract
- Objective: The Diabetes Prevention Program (DPP) is the gold standard lifestyle modification program that reduces incident type 2 diabetes mellitus. Patients with prediabetes and patients with non-alcoholic fatty liver disease (NAFLD) often share metabolic features; we hypothesized that the DPP could be adapted and used to improve outcomes in patients with NAFLD.<br />Methods: NAFLD patients were recruited into a 1 year modified DPP. Demographics, medical comorbidities, and clinical laboratory values were collected at baseline, 6 and 12 months. The primary endpoint was change in weight at 12 months. Secondary endpoints were changes in hepatic steatosis, metabolic comorbidities, and liver enzymes (per-protocol basis) and retention at 6 and 12 months.<br />Results: Fourteen NAFLD patients enrolled; three dropped out before 6 months. From baseline to 12 months, hepatic steatosis ( p  = 0.03), alanine aminotransferase ( p  = 0.02), aspartate aminotransferase ( p = 0.02), high-density lipoprotein ( p  = 0.01) and NAFLD fibrosis score ( p  < 0.001) improved, but low-density lipoprotein worsened ( p  = 0.04).<br />Conclusion: Seventy-nine percent of patients completed the modified DPP. Patients lost weight and had improvements in five out of six indicators of liver injury and lipid metabolism.<br />Clinical Trial Registry Number: NCT04988204.<br />Competing Interests: The authors declare no other conflict of interest.<br /> (© 2022 The Authors. Obesity Science & Practice published by World Obesity and The Obesity Society and John Wiley & Sons Ltd.)
Details
- Language :
- English
- ISSN :
- 2055-2238
- Volume :
- 9
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Obesity science & practice
- Publication Type :
- Academic Journal
- Accession number :
- 37287520
- Full Text :
- https://doi.org/10.1002/osp4.637