A refresh of the top 10 research priorities in cystic fibrosis.

In 2018 we published the James Lind Alliance (JLA) top 10 priorities for clinical research in cystic fibrosis (CF), chosen jointly by the patient and clinical communities. These priorities have led to new research funding. To establish whether priorities have changed with novel modulator therapies, we undertook an online international update through a series of surveys and a workshop. Patients and clinicians (n=1417) chose the refreshed top 10 from 971 new research questions (suggested by patients and clinicians) and 15 questions from 2018. We are working with the international community to promote research based on these refreshed top 10 priorities.
Competing Interests: Competing interests: NJR reports support from Cystic Fibrosis Trust for attending meetings. KC reports consultancy fees for facilitation services with James Lind Alliance and CF Trust. ARS reports a Vertex Pharmaceuticals Investigator Sponsored Study Award (paid to University of Nottingham) and consultancy fees for Viatris Advisory Board (paid to University of Nottingham), a patent (Camara M, Williams P, Barrett D, Halliday N, Knox A, Smyth A, Fogarty A, Barr H, Forrester D. Alkyl quinolones as biomarkers of pseudomonas aeruginosa infection and uses thereof. PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Patent Summary for US-2016131648-A1; [cited 2020 Nov. 17]. Available from: https://pubchem.ncbi.nlm.nih.gov/patent/US-2016131648-A1) and participation on the US CF Foundation data safety monitoring board.
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