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Natural Animal Populations as Model Systems for Understanding Early Life Adversity Effects on Aging.

Authors :
Patterson SK
Petersen RM
Brent LJN
Snyder-Mackler N
Lea AJ
Higham JP
Source :
Integrative and comparative biology [Integr Comp Biol] 2023 Sep 15; Vol. 63 (3), pp. 681-692.
Publication Year :
2023

Abstract

Adverse experiences in early life are associated with aging-related disease risk and mortality across many species. In humans, confounding factors, as well as the difficulty of directly measuring experiences and outcomes from birth till death, make it challenging to identify how early life adversity impacts aging and health. These challenges can be mitigated, in part, through the study of non-human animals, which are exposed to parallel forms of adversity and can age similarly to humans. Furthermore, studying the links between early life adversity and aging in natural populations of non-human animals provides an excellent opportunity to better understand the social and ecological pressures that shaped the evolution of early life sensitivities. Here, we highlight ongoing and future research directions that we believe will most effectively contribute to our understanding of the evolution of early life sensitivities and their repercussions.<br /> (© The Author(s) 2023. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology.)

Details

Language :
English
ISSN :
1557-7023
Volume :
63
Issue :
3
Database :
MEDLINE
Journal :
Integrative and comparative biology
Publication Type :
Academic Journal
Accession number :
37279895
Full Text :
https://doi.org/10.1093/icb/icad058