Back to Search
Start Over
Mechanobiology of Ferroptotic Cancer Cells as a Novel "Eat-Me" Signal: Regulating Efferocytosis through Layer-by-Layer Coating.
- Source :
-
Advanced healthcare materials [Adv Healthc Mater] 2023 Nov; Vol. 12 (28), pp. e2301025. Date of Electronic Publication: 2023 Jun 13. - Publication Year :
- 2023
-
Abstract
- The importance of the clearance of dead cells is shown to have a regulatory role for normal tissue homeostasis and for the modulation of immune responses. However, how mechanobiological properties of dead cells affect efferocytosis remains largely unknown. Here, it is reported that the Young's modulus of cancer cells undergoing ferroptosis is reduced. To modulate their Young's modulus a layer-by-layer (LbL) nanocoating is developed. Scanning electron and fluorescence microscopy confirm coating efficiency of ferroptotic cells while atomic force microscopy reveals encapsulation of the dead cells increases their Young's modulus dependent on the number of applied LbL layers which increases their efferocytosis by primary macrophages. This work demonstrates the crucial role of mechanobiology of dead cells in regulating their efferocytosis by macrophages which can be exploited for the development of novel therapeutic strategies for diseases where modulation of efferocytosis can be potentially beneficial and for the design of drug delivery systems for cancer therapy.<br /> (© 2023 Wiley-VCH GmbH.)
- Subjects :
- Microscopy, Atomic Force
Macrophages
Phagocytosis
Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2192-2659
- Volume :
- 12
- Issue :
- 28
- Database :
- MEDLINE
- Journal :
- Advanced healthcare materials
- Publication Type :
- Academic Journal
- Accession number :
- 37273241
- Full Text :
- https://doi.org/10.1002/adhm.202301025