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Convergent mechanisms of microglia-mediated synaptic dysfunction contribute to diverse neuropathological conditions.

Authors :
Scott-Hewitt N
Huang Y
Stevens B
Source :
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2023 Jul; Vol. 1525 (1), pp. 5-27. Date of Electronic Publication: 2023 Jun 05.
Publication Year :
2023

Abstract

Changes in synaptic function are an early hallmark of neuropathological conditions that often precede symptom onset, with mounting genetic, transcriptional, and epidemiological evidence implicating microglia in this process. The correlation between infection and neurocognitive sequelae further suggests that environmental exposures modulate neuroimmune interactions and contribute to synaptic alterations. Recent studies investigating functional roles of microglia across broad neuropathological contexts including neurodegeneration, aging, neuropsychiatric and neurodevelopmental disorders, and neurotropic infections reveal convergent mechanisms underlying microglial-mediated synaptic dysfunction. We propose that early microglial changes, driven by genetic alterations coupled with environmental neuroimmune modulation, may be a common denominator that contributes to early synaptic pathologies. Here we review the evidence and discuss how microglia respond, and contribute, to synaptopathies across diverse neurological conditions, spotlighting their importance as broadly relevant therapeutic targets within neurological diseases.<br /> (© 2023 New York Academy of Sciences.)

Details

Language :
English
ISSN :
1749-6632
Volume :
1525
Issue :
1
Database :
MEDLINE
Journal :
Annals of the New York Academy of Sciences
Publication Type :
Academic Journal
Accession number :
37272510
Full Text :
https://doi.org/10.1111/nyas.15010