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Longitudinal Associations Between Vitamin D Status and Cardiometabolic Risk Markers Among Children and Adolescents.
- Source :
-
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2023 Nov 17; Vol. 108 (12), pp. e1731-e1742. - Publication Year :
- 2023
-
Abstract
- Context: Vitamin D status has previously been associated with cardiometabolic risk markers in children and adolescents. In particular, it has been suggested that children with obesity are more prone to vitamin D deficiency and unfavorable metabolic outcomes compared with healthy-weight children.<br />Objective: To conduct a longitudinal study assessing this association in children and stratify by body mass index (BMI) category.<br />Methods: Children from the pan-European IDEFICS/I.Family cohort with at least one measurement of serum 25-hydroxyvitamin D [25(OH)D] at cohort entry or follow-up (n = 2171) were included in this study. Linear mixed-effect models were used to assess the association between serum 25(OH)D as an independent variable and z-scores of cardiometabolic risk markers (waist circumference, systolic [SBP] and diastolic blood pressure [DBP], high- [HDL] and low-density lipoprotein, non-HDL, triglycerides [TRG], apolipoprotein A1 [ApoA1] and ApoB, fasting glucose [FG], homeostatic model assessment for insulin resistance [HOMA-IR], and metabolic syndrome score) as dependent variables.<br />Results: After adjustment for age, sex, study region, smoking and alcohol status, sports club membership, screen time, BMI, parental education, and month of blood collection, 25(OH)D levels were inversely associated with SBP, DBP, FG, HOMA-IR, and TRG. The HOMA-IR z-score decreased by 0.07 units per 5 ng/mL increase in 25(OH)D. The 25(OH)D level was consistently associated with HOMA-IR irrespective of sex or BMI category.<br />Conclusion: Low serum 25(OH)D concentrations are associated with unfavorable levels of cardiometabolic markers in children and adolescents. Interventions to improve vitamin D levels in children with a poor status early in life may help to reduce cardiometabolic risk.<br /> (© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Humans
Child
Adolescent
Longitudinal Studies
Vitamin D
Vitamins
Triglycerides
Body Mass Index
Cardiovascular Diseases epidemiology
Cardiovascular Diseases etiology
Metabolic Syndrome epidemiology
Metabolic Syndrome complications
Vitamin D Deficiency complications
Vitamin D Deficiency epidemiology
Insulin Resistance
Subjects
Details
- Language :
- English
- ISSN :
- 1945-7197
- Volume :
- 108
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The Journal of clinical endocrinology and metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 37261399
- Full Text :
- https://doi.org/10.1210/clinem/dgad310