USP18 regulates the malignant phenotypes of glioblastoma stem cells.

Authors :: Li L
Yin Y
Zhang J
Wu X
Liu J
Chai J
Yang Y
Li M
Jia Q
Liu Y
Source :: Pathology, research and practice [Pathol Res Pract] 2023 Jul; Vol. 247, pp. 154572. Date of Electronic Publication: 2023 May 25.
Publication Year :: 2023
Abstract: Glioblastoma (GBM) is the most malignant primary brain tumor. The 5-year survival rate of the patients is poor, and they are prone to relapse and the treatment is limited. Therefore, the search for biological targets is one of the key measures for the treatment and prognosis of GBM. Ubiquitin-specific peptidase 18 (USP18) plays a regulatory role in tumorigenesis. In this study, we found that USP18 was up-regulated in GBM, promoted the growth and proliferation of glioblastoma stem cells (GSCs), affected the epithelial-mesenchymal transition (EMT), and was associated with poor clinical prognosis of patients. Finally, our findings reveal a critical role for USP18 in GBM malignancy, targeting USP18 may open new avenues for GBM treatment.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no conflict of interest.<br /> (Copyright © 2023 Elsevier GmbH. All rights reserved.)