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Measuring and modeling macrophage proliferation in a lab-on-CMOS capacitance sensing microsystem.
- Source :
-
Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2023 May 12; Vol. 11, pp. 1159004. Date of Electronic Publication: 2023 May 12 (Print Publication: 2023). - Publication Year :
- 2023
-
Abstract
- We report on the use of a lab-on-CMOS biosensor platform for quantitatively tracking the proliferation of RAW 264.7 murine Balb/c macrophages. We show that macrophage proliferation correlates linearly with an average capacitance growth factor resulting from capacitance measurements at a plurality of electrodes dispersed in a sensing area of interest. We further show a temporal model that captures the cell number evolution in the area over long periods (e.g., 30 h). The model links the cell numbers and the average capacitance growth factor to describe the observed cell proliferation.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2023 Smith, Lin, Gilpin, Wayne and Dandin.)
Details
- Language :
- English
- ISSN :
- 2296-4185
- Volume :
- 11
- Database :
- MEDLINE
- Journal :
- Frontiers in bioengineering and biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 37251577
- Full Text :
- https://doi.org/10.3389/fbioe.2023.1159004