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Characteristics of the right atrial and right ventricular contractility in a model of monocrotaline-induced pulmonary arterial hypertension.

Characteristics of the right atrial and right ventricular contractility in a model of monocrotaline-induced pulmonary arterial hypertension.

Authors :
Gerzen OP
Lisin RV
Balakin AA
Mukhlynina EA
Kuznetsov DA
Nikitina LV
Protsenko YL
Source :
Journal of muscle research and cell motility [J Muscle Res Cell Motil] 2023 Dec; Vol. 44 (4), pp. 299-309. Date of Electronic Publication: 2023 May 30.
Publication Year :
2023

Abstract

Pulmonary arterial hypertension (PAH) leads to changes in the pump function of the heart and causes right-sided myocardial hypertrophy and heart failure. This study was the first to compare the contractile characteristics of the multicellular myocardial preparations of the right atrium (RA) and right ventricle (RV) of male rats from the control group (CON) and the group with monocrotaline (MCT)-induced hypertrophy at the molecular and multicellular levels. In both RA and RV in MCT-treated rats, the fraction of motile filaments and the maximum sliding velocity of actin and reconstituted thin filaments over myosin decreased, and the ratio of α-/β-myosin heavy chains (MHC) shifted towards β-MHC. In the RA strips and RV trabeculae, the maximum shortening velocity, the extent of muscle shortening, the amplitude of isometric stress, the amount of work decreased. PAH leads to a greater drop in right atrial contractility than that of the ventricle.<br /> (© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

Details

Language :
English
ISSN :
1573-2657
Volume :
44
Issue :
4
Database :
MEDLINE
Journal :
Journal of muscle research and cell motility
Publication Type :
Academic Journal
Accession number :
37249732
Full Text :
https://doi.org/10.1007/s10974-023-09651-7