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Curcumin displays a potent caloric restriction mimetic effect in an accelerated senescent model of rat.
- Source :
-
Biologia futura [Biol Futur] 2023 Jun; Vol. 74 (1-2), pp. 221-229. Date of Electronic Publication: 2023 May 29. - Publication Year :
- 2023
-
Abstract
- Curcumin, a strong natural compound with numerous health benefits, is extracted from the Curcuma longa. According to recent research findings, it also acts as a calorie restriction mimetic. We examined established aging biomarkers in erythrocytes and plasma and tested a persistent oral dietary dose of curcumin in young and D-galactose-induced accelerated rat aging models. For four weeks, D-gal (300 mg/kg b.w. subcutaneously) and curcumin (200 mg/kg b.w. oral) were administered simultaneously to test the protective effects of curcumin against D-galactose-induced accelerated aging and oxidative stress. In the accelerated senescent rat model, we discovered a significant rise in protein carbonyl, malonaldehyde (MDA), and advanced oxidation protein products. Increased levels of catalase, superoxide dismutase, ferric-reducing antioxidant potential, and reduced glutathione (GSH) were observed. Our findings reveal that curcumin has characteristics resembling a calorie restriction mimic and can successfully maintain redox equilibrium throughout the aging process in rat erythrocytes and plasma.<br /> (© 2023. Akadémiai Kiadó Zrt.)
Details
- Language :
- English
- ISSN :
- 2676-8607
- Volume :
- 74
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Biologia futura
- Publication Type :
- Academic Journal
- Accession number :
- 37247086
- Full Text :
- https://doi.org/10.1007/s42977-023-00170-7