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Orofacial anti-hypernociceptive effect of citral in acute and persistent inflammatory models in rats.

Authors :
Santos BM
Santos WS
Solon IG
Garcia FS
Emilio-Silva MT
Jesus AA
Hiruma-Lima CA
Nascimento GC
Cárnio EC
Branco LGS
Source :
Archives of oral biology [Arch Oral Biol] 2023 Aug; Vol. 152, pp. 105734. Date of Electronic Publication: 2023 May 22.
Publication Year :
2023

Abstract

Orofacial pain has significant psychological and physiological effects. Citral (3,7-dimethyl-2,6-octadienal) is the main component of Cymbopogon citratus (DC) Stapf, an herb with analgesic properties. Although citral has been considered a potent analgesic, its putative effects on orofacial pain are still unknown.<br />Objective: The objective of this study is to test the hypothesis that citral modulates orofacial pain using two experimental models: formalin-induced hyperalgesia in the vibrissae area and during persistent temporomandibular hypernociception using Complete Freund's Adjuvant - CFA test.<br />Methods: For the formalin test, citral (100 and 300 mg/kg, oral gavage) or its vehicle (Tween 80, 1 %) were given 1 h before the formalin injection subcutaneously (sc) into the vibrissae area. For the CFA model, we analyzed the prophylactic (100 mg/kg of citral by oral gavage, 1 h before CFA injection) and the chronic therapeutic (citral treatment 1-hour post-CFA injection and daily post-CFA injection) effect of citral or its vehicle in animals treated with CFA for 8 days.<br />Results: Citral caused a decrease in formalin-induced local inflammation and the time spent performing nociceptive behavior in a dose-dependent fashion. Similarly, prophylactic and therapeutic citral treatment decreased the CFA-induced persistent mechanical hypernociception in the temporomandibular area.<br />Conclusion: Our data strengthen the notion that citral plays a powerful antinociceptive role by decreasing orofacial hypernociception in formalin and CFA models.<br />Competing Interests: Declaration of Competing Interest The authors have not disclosed any conflicts of interest.<br /> (Copyright © 2023 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1879-1506
Volume :
152
Database :
MEDLINE
Journal :
Archives of oral biology
Publication Type :
Academic Journal
Accession number :
37244090
Full Text :
https://doi.org/10.1016/j.archoralbio.2023.105734