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COVID-19: Focusing on the Link between Inflammation, Vitamin D, MAPK Pathway and Oxidative Stress Genetics.
- Source :
-
Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2023 May 20; Vol. 12 (5). Date of Electronic Publication: 2023 May 20. - Publication Year :
- 2023
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Abstract
- An uncontrolled inflammatory response during SARS-CoV-2 infection has been highlighted in several studies. This seems to be due to pro-inflammatory cytokines whose production could be regulated by vitamin D, ROS production or mitogen-activated protein kinase (MAPK). Several genetic studies are present in the literature concerning genetic influences on COVID-19 characteristics, but there are few data on oxidative stress, vitamin D, MAPK and inflammation-related factors, considering gender and age. Therefore, the aim of this study was to evaluate the role of single nucleotide polymorphisms in these pathways, clarifying their impact in affecting COVID-19-related clinical features. Genetic polymorphisms were evaluated through real-time PCR. We prospectively enrolled 160 individuals: 139 patients were positive for SARS-CoV-2 detection. We detected different genetic variants able to affect the symptoms and oxygenation. Furthermore, two sub-analyses were performed considering gender and age, showing a different impact of polymorphisms according to these characteristics. This is the first study highlighting a possible contribution of genetic variants of these pathways in affecting COVID-19 clinical features. This may be relevant in order to clarify the COVID-19 etiopathogenesis and to understand the possible genetic contribution for further SARS infections.
Details
- Language :
- English
- ISSN :
- 2076-3921
- Volume :
- 12
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Antioxidants (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 37237997
- Full Text :
- https://doi.org/10.3390/antiox12051133