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COVID-19 infected ST-Elevation myocardial infarction in India (COSTA INDIA).

Authors :: Jabir A
Geevar Zachariah
Mohanan PP
Gupta MD
Ramakrishnan S
Meena CB
Sridhar L
Girish MP
Das DR
Gupta A
Praveen Nagula
Tom Devasia
Bhavesh Vajifdar
Kamlesh Thakkar
Urmil Shah
Tanuj Bhatia
Smit Srivastava
Sanjeev Sharma
Priya Kubendiran
Jayagopal PB
Sudeep Kumar
Deepthy Sadanandan
Lincy Mathew
Nitish Naik
Anup Banerji
Ashraf SM
Asokan PK
Bharti BB
Majumder B
Dhiman Kahali
Sinha DP
Sharma D
Dastidar DG
Dipankar Mukhapdhyay
Wander GS
Bali HK
Kesavamoorthy B
Agarwala MK
Khanna NN
Natesh BH
Goel PK
Chakraborty RN
Jain RK
Rakesh Yadav
Sameer Dani L
Satyavan Sharma
Satyendra Tewari
Sethi KK
Sharad Chandra
Mandal S
Bhandari S
Sikdar S
Vivek Gupta
Rath PC
Bang VH
Debabrata Roy
Das MK
Banerjee PS
Source :: Indian heart journal [Indian Heart J] 2023 Jul-Aug; Vol. 75 (4), pp. 243-250. Date of Electronic Publication: 2023 May 23.
Publication Year :: 2023
Abstract: Objective: To find out differences in the presentation, management and outcomes of COVID-19 infected STEMI patients compared to age and sex-matched non-infected STEMI patients treated during the same period.<br />Methods: This was a retrospective multicentre observational registry in which we collected data of COVID-19 positive STEMI patients from selected tertiary care hospitals across India. For every COVID-19 positive STEMI patient, two age and sex-matched COVID-19 negative STEMI patients were enrolled as control. The primary endpoint was a composite of in-hospital mortality, re-infarction, heart failure, and stroke.<br />Results: 410 COVID-19 positive STEMI cases were compared with 799 COVID-19 negative STEMI cases. The composite of death/reinfarction/stroke/heart failure was significantly higher among the COVID-19 positive STEMI patients compared with COVID-19 negative STEMI cases (27.1% vs 20.7% p value = 0.01); though mortality rate did not differ significantly (8.0% vs 5.8% p value = 0.13). Significantly lower proportion of COVID-19 positive STEMI patients received reperfusion treatment and primary PCI (60.7% vs 71.1% p value=< 0.001 and 15.4% vs 23.4% p value = 0.001 respectively). Rate of systematic early PCI (pharmaco-invasive treatment) was significantly lower in the COVID-19 positive group compared with COVID-19 negative group. There was no difference in the prevalence of high thrombus burden (14.5% and 12.0% p value = 0.55 among COVID-19 positive and negative patients respectively) CONCLUSIONS: In this large registry of STEMI patients, we did not find significant excess in in-hospital mortality among COVID-19 co-infected patients compared with non-infected patients despite lower rate of primary PCI and reperfusion treatment, though composite of in-hospital mortality, re-infarction, stroke and heart failure was higher.<br /> (Copyright © 2023 Cardiological Society of India. Published by Elsevier, a division of RELX India, Pvt. Ltd. All rights reserved.)