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Long-term follow-up of dermatitis herpetiformis in children.
- Source :
-
Journal of the American Academy of Dermatology [J Am Acad Dermatol] 1986 Jul; Vol. 15 (1), pp. 24-30. - Publication Year :
- 1986
-
Abstract
- Dermatitis herpetiformis was diagnosed in seventy-six children by its clinical features and by detection of granular IgA deposits in the papillary dermis of perilesional skin. Enteric alterations demonstrated by measurement of D-xylose absorption and by small intestinal biopsies were detected in over 90% of all patients. A complete follow-up was obtained for all children who were followed for 3 to 10 years. Treatment with a gluten-free diet alone led to a reversal of the intestinal abnormality in 100% of our children and to the disappearance of cutaneous lesions in 82% of reported cases. This suggests that a complete remission of symptoms can be obtained with a gluten-free diet alone. Dapsone alone is effective therapy for the rash but does not affect the intestinal alterations. Furthermore, the lack of side effects to dietetic therapy for a long period of time makes the diet the treatment of choice in this disease.
- Subjects :
- Child
Child, Preschool
Combined Modality Therapy
Dapsone adverse effects
Dapsone therapeutic use
Dermatitis Herpetiformis diet therapy
Dermatitis Herpetiformis drug therapy
Dermatitis Herpetiformis pathology
Female
Follow-Up Studies
Glutens
Humans
Jejunum pathology
Male
Recurrence
Dermatitis Herpetiformis therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0190-9622
- Volume :
- 15
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of the American Academy of Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 3722506
- Full Text :
- https://doi.org/10.1016/s0190-9622(86)70137-0