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The versatile defender: exploring the multifaceted role of p62 in intracellular bacterial infection.
- Source :
-
Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2023 May 05; Vol. 13, pp. 1180708. Date of Electronic Publication: 2023 May 05 (Print Publication: 2023). - Publication Year :
- 2023
-
Abstract
- As a highly conserved, multifunctional protein with multiple domains, p62/SQSTM1 plays a crucial role in several essential cellular activities, particularly selective autophagy. Recent research has shown that p62 is crucial in eradicating intracellular bacteria by xenophagy, a selective autophagic process that identifies and eliminates such microorganisms. This review highlights the various roles of p62 in intracellular bacterial infections, including both direct and indirect, antibacterial and infection-promoting aspects, and xenophagy-dependent and independent functions, as documented in published literature. Additionally, the potential applications of synthetic drugs targeting the p62-mediated xenophagy mechanism and unresolved questions about p62's roles in bacterial infections are also discussed.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2023 Zhou, Hua and Song.)
- Subjects :
- Humans
Autophagy
Bacterial Infections
Sequestosome-1 Protein metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2235-2988
- Volume :
- 13
- Database :
- MEDLINE
- Journal :
- Frontiers in cellular and infection microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 37216179
- Full Text :
- https://doi.org/10.3389/fcimb.2023.1180708