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Thyroid Autoimmunity and Subclinical Hypothyroidism in Prolactinoma: A Case Control Study.

Authors :
Laway BA
Sahu D
Bhat MH
Baba MS
Viswanath SA
Misgar RA
Wani AI
Bashir MI
Shah ZA
Mudassar S
Source :
Indian journal of endocrinology and metabolism [Indian J Endocrinol Metab] 2023 Jan-Feb; Vol. 27 (1), pp. 45-49. Date of Electronic Publication: 2022 Apr 29.
Publication Year :
2023

Abstract

Background: This study was aimed at determining the frequency of thyroid autoimmunity and subclinical hypothyroidism in patients with hyperprolactinemia due to prolactinoma compared to well-matched healthy controls.<br />Methods: This was a cross-sectional study wherein 78 treatment naïve prolactinoma patients and ninety-two healthy control subjects were recruited. Serum prolactin (PRL), thyroid-stimulating hormone (TSH), total thyroxine (T4), circulating anti-thyroid peroxidase (anti-TPO), and anti-thyroglobulin (anti-Tg) antibody levels were measured in all study subjects. Progression of the antibody-positive population to subclinical hypothyroidism was determined.<br />Results: The median PRL level among patients was 166 ng/ml (IQR 85-467) compared to 11.4 ng/ml (IQR 8.5-15.9) in controls ( P < 0.001). There was no significant difference in levels of T4 ( P = 0.83) and TSH ( P = 0.82) between the cases and controls. Overall, 25% of patients had the presence of anti-thyroid antibodies as compared to 20% of controls ( P = 0.56). SCH was more common in antibody-positive hyperprolactinemia subjects compared with antibody-positive controls.<br />Conclusion: We did not find an increased prevalence of thyroid autoimmunity among untreated prolactinoma patients compared to healthy controls. At the same time, subclinical hypothyroidism was more common in thyroid antibody-positive patients with hyperprolactinemia than positive controls.<br />Competing Interests: There are no conflicts of interest.<br /> (Copyright: © 2022 Indian Journal of Endocrinology and Metabolism.)

Details

Language :
English
ISSN :
2230-8210
Volume :
27
Issue :
1
Database :
MEDLINE
Journal :
Indian journal of endocrinology and metabolism
Publication Type :
Academic Journal
Accession number :
37215267
Full Text :
https://doi.org/10.4103/ijem.ijem_425_21