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Diabetes and prediabetes in children with cystic fibrosis.
- Source :
-
Current opinion in pediatrics [Curr Opin Pediatr] 2023 Aug 01; Vol. 35 (4), pp. 481-485. Date of Electronic Publication: 2023 Jun 02. - Publication Year :
- 2023
-
Abstract
- Purpose of Review: Glucose metabolism alterations in cystic fibrosis range from the classic cystic fibrosis-related diabetes (CFRD) to forms of glucose intolerance and prediabetes. The aim of the present work is to review the most up-to-date novelties in terms of CFRD diagnosis and therapy. This review is timely and relevant because it allows an update for the early and correct classification of glucose abnormalities in cystic fibrosis and because it favours an appropriate therapeutic approach.<br />Recent Findings: Confirm that Oral Glucose Tolerance Test is still the diagnostic gold standard despite the advent of continuous glucose monitoring (CGM) systems; this latter is spreading very rapidly, however, to date, there is still no strong evidence to hypothesize the use of CGM for diagnostic purposes. CGM has indeed proven to be very useful in managing and guiding CFRD therapy.<br />Summary: Tailored and personalized insulin therapy is still the recommended therapy for children and adolescents with CFRD, although nutritional intervention and oral hypoglycaemic treatment are equally important and efficacious. Finally CFTR modulators have allowed the increase of the life expectancy of cystic fibrosis patients and have proven effective not only in improving the pulmonary function and the nutritional status but also the glucose control.<br /> (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.)
- Subjects :
- Adolescent
Humans
Child
Blood Glucose Self-Monitoring adverse effects
Blood Glucose metabolism
Insulin therapeutic use
Prediabetic State diagnosis
Prediabetic State therapy
Prediabetic State complications
Cystic Fibrosis complications
Cystic Fibrosis diagnosis
Cystic Fibrosis therapy
Diabetes Mellitus diagnosis
Diabetes Mellitus etiology
Diabetes Mellitus therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1531-698X
- Volume :
- 35
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Current opinion in pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 37211992
- Full Text :
- https://doi.org/10.1097/MOP.0000000000001259