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Test-retest repeatability of organ uptake on PSMA-targeted 18 F-DCFPyL PET/CT in patients with prostate cancer.
- Source :
-
The Prostate [Prostate] 2023 Sep; Vol. 83 (12), pp. 1186-1192. Date of Electronic Publication: 2023 May 21. - Publication Year :
- 2023
-
Abstract
- Objectives: We evaluated <superscript>18</superscript> F-DCFPyL test-retest repeatability of uptake in normal organs.<br />Methods: Twenty-two prostate cancer (PC) patients underwent two <superscript>18</superscript> F-DCFPyL PET scans within 7 days within a prospective clinical trial (NCT03793543). In both PET scans, uptake in normal organs (kidneys, spleen, liver, and salivary and lacrimal glands) was quantified. Repeatability was determined by using within-subject coefficient of variation (wCOV), with lower values indicating improved repeatability.<br />Results: For SUV <subscript>mean</subscript> , repeatability was high for kidneys, spleen, liver, and parotid glands (wCOV, range: 9.0%-14.3%) and lower for lacrimal (23.9%) and submandibular glands (12.4%). For SUV <subscript>max</subscript> , however, the lacrimal (14.4%) and submandibular glands (6.9%) achieved higher repeatability, while for large organs (kidneys, liver, spleen, and parotid glands), repeatability was low (range: 14.1%-45.2%).<br />Conclusion: We found acceptable repeatability of uptake on <superscript>18</superscript> F-DCFPyL PET for normal organs, in particular for SUV <subscript>mean</subscript> in the liver or parotid glands. This may have implications for both PSMA-targeted imaging and treatment, as patient selection for radioligand therapy and standardized frameworks for scan interpretation (PROMISE, E-PSMA) rely on uptake in those reference organs.<br /> (© 2023 The Authors. The Prostate published by Wiley Periodicals LLC.)
Details
- Language :
- English
- ISSN :
- 1097-0045
- Volume :
- 83
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The Prostate
- Publication Type :
- Academic Journal
- Accession number :
- 37211963
- Full Text :
- https://doi.org/10.1002/pros.24577