Reducing segmentation failures in cardiac MRI via late feature fusion and GAN-based augmentation.

Cardiac magnetic resonance (CMR) image segmentation is an integral step in the analysis of cardiac function and diagnosis of heart related diseases. While recent deep learning-based approaches in automatic segmentation have shown great promise to alleviate the need for manual segmentation, most of these are not applicable to realistic clinical scenarios. This is largely due to training on mainly homogeneous datasets, without variation in acquisition, which typically occurs in multi-vendor and multi-site settings, as well as pathological data. Such approaches frequently exhibit a degradation in prediction performance, particularly on outlier cases commonly associated with difficult pathologies, artifacts and extensive changes in tissue shape and appearance. In this work, we present a model aimed at segmenting all three cardiac structures in a multi-center, multi-disease and multi-view scenario. We propose a pipeline, addressing different challenges with segmentation of such heterogeneous data, consisting of heart region detection, augmentation through image synthesis and a late-fusion segmentation approach. Extensive experiments and analysis demonstrate the ability of the proposed approach to tackle the presence of outlier cases during both training and testing, allowing for better adaptation to unseen and difficult examples. Overall, we show that the effective reduction of segmentation failures on outlier cases has a positive impact on not only the average segmentation performance, but also on the estimation of clinical parameters, leading to a better consistency in derived metrics.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Marcel Breeuwer is an employee of Philips Medical Systems B.V. Cristian Lorenz and Jürgen Weese are employees of Philips GmbH Innovative Technologies.
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