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Long-term analysis of adrenocorticotropic hormone monotherapy for infantile epileptic spasms syndrome with periventricular leukomalacia.
- Source :
-
Seizure [Seizure] 2023 Jul; Vol. 109, pp. 40-44. Date of Electronic Publication: 2023 May 16. - Publication Year :
- 2023
-
Abstract
- Purpose: Infantile epileptic spasms syndrome (IESS) with periventricular leukomalacia (PVL) has a poor neurological prognosis. Adrenocorticotropic hormone (ACTH) and vigabatrin therapies are the recommended first-line treatments for IESS. However, ACTH monotherapy for IESS with PVL has not been studied in detail. We analysed long-term outcomes of ACTH monotherapy for IESS with PVL.<br />Methods: We retrospectively examined 12 patients with IESS and PVL at Saitama Children's Medical Center between January 1993 and September 2022. We evaluated seizure outcomes 3 months post-ACTH therapy and at the last visit. We also assessed electroencephalography findings and developmental outcomes. A positive response was defined as complete remission of epileptic spasms, no other seizure types, and hypsarrhythmia resolution post-ACTH therapy.<br />Results: The median onset age of epileptic spasms was 7 (range: 3-14) months. The median age at initiation of ACTH therapy was 9 (7-17) months. Seven of 12 patients (58.3%) showed a positive response. The median age at the last visit was 5 years and 6 months (1 year and 5 months-22 years and 2 months). At the last visit, only 2 of 7 initial responders remained seizure-free who demonstrated normal electroencephalography findings within 1-month post-ACTH therapy. Patients with epileptic discharge in the parieto-occipital region within 1-month post-ACTH therapy showed relapse of epileptic spasms or other seizure types.<br />Conclusion: Patients having epileptic discharge in the parietal or occipital regions on electroencephalography within 1-month post-ACTH therapy may be at a high risk of epileptic spasm recurrence or other seizure types in the long term.<br />Competing Interests: Declaration of Competing Interest Shin-ichiro Hamano has received research funding from Syneos Health Clinical Co. Ltd for the clinical trial of Zogenix and has received funds for speaker honoraria and travel from UCB Japan Co. Ltd., Daiichi Sankyo Co. Ltd., and Eisai Co. Ltd. Kenjiro Kikuchi has received research funding from Janssen Pharmaceutical K.K. and Syneos Health Clinical Co. Ltd. for clinical trial of Zogenix. The other authors have nothing to disclose in terms of conflict of interest.<br /> (Copyright © 2023 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Infant, Newborn
Child
Humans
Infant
Adrenocorticotropic Hormone therapeutic use
Treatment Outcome
Retrospective Studies
Electroencephalography
Syndrome
Seizures drug therapy
Spasm drug therapy
Anticonvulsants therapeutic use
Leukomalacia, Periventricular complications
Leukomalacia, Periventricular drug therapy
Spasms, Infantile drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2688
- Volume :
- 109
- Database :
- MEDLINE
- Journal :
- Seizure
- Publication Type :
- Academic Journal
- Accession number :
- 37207538
- Full Text :
- https://doi.org/10.1016/j.seizure.2023.05.012