Back to Search
Start Over
Revisiting Aire and tissue-restricted antigens at single-cell resolution.
- Source :
-
Frontiers in immunology [Front Immunol] 2023 May 03; Vol. 14, pp. 1176450. Date of Electronic Publication: 2023 May 03 (Print Publication: 2023). - Publication Year :
- 2023
-
Abstract
- The thymus is a highly specialized organ that plays an indispensable role in the establishment of self-tolerance, a process characterized by the "education" of developing T-cells. To provide competent T-cells tolerant to self-antigens, medullary thymic epithelial cells (mTECs) orchestrate negative selection by ectopically expressing a wide range of genes, including various tissue-restricted antigens (TRAs). Notably, recent advancements in the high-throughput single-cell analysis have revealed remarkable heterogeneity in mTECs, giving us important clues for dissecting the mechanisms underlying TRA expression. We overview how recent single-cell studies have furthered our understanding of mTECs, with a focus on the role of Aire in inducing mTEC heterogeneity to encompass TRAs.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2023 Matsumoto, Yoshida, Tsuneyama, Oya and Matsumoto.)
Details
- Language :
- English
- ISSN :
- 1664-3224
- Volume :
- 14
- Database :
- MEDLINE
- Journal :
- Frontiers in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 37207224
- Full Text :
- https://doi.org/10.3389/fimmu.2023.1176450