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Theranostics of Primary Prostate Cancer: Beyond PSMA and GRP-R.
- Source :
-
Cancers [Cancers (Basel)] 2023 Apr 18; Vol. 15 (8). Date of Electronic Publication: 2023 Apr 18. - Publication Year :
- 2023
-
Abstract
- The imaging of Prostate-Specific Membrane Antigen (PSMA) is now widely used at the initial staging of prostate cancers in patients with a high metastatic risk. However, its ability to detect low-grade tumor lesions is not optimal.<br />Methods: First, we prospectively performed neurotensin receptor-1 (NTS <subscript>1</subscript> ) IHC in a series of patients receiving both [ <superscript>68</superscript> Ga]Ga-PSMA-617 and [ <superscript>68</superscript> Ga]Ga-RM2 before prostatectomy. In this series, PSMA and GRP-R IHC were also available (n = 16). Next, we aimed at confirming the PSMA/GRP-R/NTS <subscript>1</subscript> expression profile by retrospective autoradiography (n = 46) using a specific radiopharmaceuticals study and also aimed to decipher the expression of less-investigated targets such as NTS <subscript>2</subscript> , SST <subscript>2</subscript> and CXCR4.<br />Results: In the IHC study, all samples with negative PSMA staining (two patients with ISUP 2 and one with ISUP 3) were strongly positive for NTS <subscript>1</subscript> staining. No samples were negative for all three stains-for PSMA, GRP-R or NTS <subscript>1</subscript> . In the autoradiography study, binding of [ <superscript>111</superscript> In]In-PSMA-617 was high in all ISUP groups. However, some samples did not bind or bound weakly to [ <superscript>111</superscript> In]In-PSMA-617 (9%). In these cases, binding of [ <superscript>111</superscript> n]In-JMV 6659 and [ <superscript>111</superscript> In]In-JMV 7488 towards NTS <subscript>1</subscript> and NTS <subscript>2</subscript> was high.<br />Conclusions: Targeting PSMA and NTS <subscript>1</subscript> /NTS <subscript>2</subscript> could allow for the detection of all intraprostatic lesions.
Details
- Language :
- English
- ISSN :
- 2072-6694
- Volume :
- 15
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Cancers
- Publication Type :
- Academic Journal
- Accession number :
- 37190273
- Full Text :
- https://doi.org/10.3390/cancers15082345